2-DEOXY-D-GLUCOSE ENHANCES DICHLOROACETATE ANTITUMOR ACTION AGAINST LEWIS LUNG CARCINOMA
نویسندگان
چکیده
منابع مشابه
2-Deoxy-D-glucose enhances dichloroacetate antitumor action against Lewis lung carcinoma.
UNLABELLED Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism capable of suppressing tumor growth and metastasis could result in higher effectiveness of anticancer therapy. AIM To study antitumor and antimetastatic activity of ...
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Pyran (copolymer of divinyl ether and maleic anhydride) and tilorone [2,7-bis(2-diethylaminoethoxy) fluoren-9-one dihydrochloride] are host resistance-inducing agents that possess antitumor activity. The possible relationship of direct cytotoxicity to antitumor activity against the Lewis lung carcinoma and B-16 melanoma tumors was examined. Tilorone and tilorone congeners exhibited significant ...
متن کاملEffect of dichloroacetate on Lewis lung carcinoma growth and metastasis.
UNLABELLED A hallmark of malignancy is excessive tumor glycolysis, even in the presence of oxygen, which causes lactacidosis in the tumor microenvironment and favors tumor cell proliferation and survival. For this reason antimetabolic agents which target tumor cell metabolism are being researched extensively as promising anticancer drugs. AIM To study the effect of lactacidosis on survival of...
متن کاملAconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma.
UNLABELLED Significant variability of anticancer efficacy of dichloroacetate (DCA) stimulated an active search for the agents capable to enhance it antitumor action. Therefore, the aim of this work is the study of capability of aconitine-containing antiangiogenic agent BC1 to enhance anticancer activity of DCA against Ehrlich carcinoma. MATERIALS AND METHODS DCA (total dose was 1.3 g/kg of b....
متن کاملHypoxia enhances antitumor activity of dichloroacetate.
UNLABELLED It is known that glycolysis contributes to the survival of tumor cells by providing them with energetic and plastic substrates. Dichloroacetate (DCA) as inhibitor of kinase pyruvate dehydrogenase shifts balance of energy metabolism of tumor cells from aerobic glycolysis towards oxidative phosphorylation. The aim of the study was to investigate cytostatic/cytotoxic effect of DCA on gl...
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ژورنال
عنوان ژورنال: Experimental Oncology
سال: 2016
ISSN: 2312-8852,1812-9269
DOI: 10.31768/2312-8852.2016.38(3):176-180